Onychomycosis: role of non dermatophytes

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Rapid detection of dermatophytes and Candida albicansin onychomycosis specimens by an oligonucleotide array

BACKGROUND Onychomycosis is a fungal infection of nails, leading to the gradual destruction of the nail plate. Treatment of onychomycosis may need long-time oral antifungal therapy that can have potential side effects, thus accurate diagnosis of the disease before treatment is important. Culture for diagnosis of onychomycosis is time-consuming and has high false-negative rates. To expedite the ...

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An in-office diagnostic procedure to detect dermatophytes in a nationwide study of onychomycosis patients.

PURPOSE To evaluate in-office dermatophyte test medium (DTM) culture as an alternative to traditional laboratory fungal culture for confirming a diagnosis of onychomycosis, and to determine the prevalence of dermatophytes as a cause of onychomycosis in patients not participating in a clinical trial. DESIGN This nationwide multicenter prospective study enrolled 1100 adult patients with suspect...

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In vitro antifungal oral drug and drug-combination activity against onychomycosis causative dermatophytes.

We present the results of studies of the in vitro susceptibility of 52 isolates of Trichophyton rubrum and 40 of Trichophyton mentagrophytes to griseofulvin, terbinafine, itraconazole, ketoconazole, fluconazole and cyclopiroxolamine. All test strains were recovered from patients with toe nail onychomycosis and the minimum inhibitory concentration (MIC) of each antifungal against both species wa...

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Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis.

The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of l...

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Non-dermatophyte moulds as pathogens of onychomycosis.

OBJECTIVE To determine the role and pattern of non-dermatophyte moulds as causative agents of onychomycosis. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY Department of Microbiology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from November 2009 to July 2010. METHODOLOGY Nail clippings and nail scrapings were obtained from abnormal looking nails with treatment and dete...

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ژورنال

عنوان ژورنال: International Journal of Advances in Medicine

سال: 2016

ISSN: 2349-3925

DOI: 10.18203/2349-3933.ijam20162510